Biomedical Engineering, Medical Imaging, Magnetic Resonance, MRI, NMR, ESR
I am full professor and head of Center for Magnetic
Resonance. I am also center leader for Center for
Hyperpolarization in Magnetic Resonance, a center of
excellence funded by the Danish National Research Foundation.
My research has always evolved around means to improve the
sensitivity of Magnetic Resonance (MR) Imaging and Spectroscopy,
with the aim of obtaining new, and otherwise inaccessible,
information about function and disease at the cellular and
molecular levels. These means have typically been unconventional
and involved novel chemistry, physics and engineering.
In 2003 we demonstrated a more than 10,000-fold enhancement of
the sensitivity of the Nuclear Magnetic Resonance signal by the
dissolution Dynamic Nuclear Polarization (DNP) method. The
invention has enabled MR Metabolic Imaging in real time. In 2013 we
published the first clinical study in patients with prostate cancer
using hyperpolarized 13C-pyruvate. For this invention I was
awarded the Günther Laukien Prize by ENC in 2012 and the Gold
Medal Award by the World Molecular Imaging Society in 2014. My
current research relates to understanding the physics of DNP and
improving the method and instrumentation to further enhance and
accelerate DNP, improving the sensitivity of detection in MRI by
new hardware and imaging strategies, as well as the clinical
translation of hyperpolarization to medical imaging.
In addition to my research on hyperpolarization I have made
significant scientific contributions to two novel magnetic
resonance imaging techniques: electron paramagnetic resonance
imaging (EPRI) and Overhauser magnetic resonance imaging (OMRI)
through the development and characterization of novel organic
radicals, development of instrumentation and methodology.